MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria
Fig 3
Mpv17 ablation results in a marked increase of mtDNA replication intermediates.
Analysis of mtDNA replication intermediates in the liver of WT and Mpv17-/- mice. Mitochondrial DNAs from six Mpv17-/- and six control livers were isolated, digested with BclI and fractionated by 2D-AGE and blot hybridized to a probe to the major non-coding region (NCR) of the murine mitochondrial genome.