Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain
Fig 8
Acer3 knockout induces hindlimb clasping phenotype in mice.
A and B. Hindlimb clasping reflex tests. Hindlimb clasping reflex was scored in Acer3+/+ and Acer3-/- mice at 6W, 4M, 6M, 8M, and 12M of age (A). At 8M of age, Acer3+/+ splayed their hindlimbs outward and away from the abdomen similar to what was seen in the 6W mice, whereas Acer3-/- mice retracted their hindlimbs toward the abdomen into a clasping reflex (B). The data in A represent mean values ± SD, n = 5–8. n.s., not significant.