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Coordinated Evolution of Influenza A Surface Proteins

Fig 5

Numbers of leading and trailing mutations at putatively epistatic site pairs in different gene pairs.

Circle area corresponds to the number of site pairs with each number of leading and trailing mutations at liberal (grey) or conservative (orange) P-value thresholds. To gauge the scale, the numbers of pairs at conservative P-value thresholds are shown next to the orange circles.

Fig 5

doi: https://doi.org/10.1371/journal.pgen.1005404.g005