Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation
Figure 5
Chromatin state organizes p53 occupancy and gene transactivation.
(A) P53-upregulated genes are grouped by ChromHMM at TSS. Genes with CTCF insulation at the TSS prior to treatment were associated with the largest change in gene expression (fold change +/− SEM). Genes displayed in Fig. 4 are examples. (B) Balloon plot depicts the correlation between peak density and change in gene expression after stratifying by ChromHMM state at the TSS. Linear regression was performed on means of the log2 values for each chromatin state and the trend line shown. The size of the circles indicates the relative number of genes in each group.