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The Functional Consequences of Variation in Transcription Factor Binding

Figure 3

Intersecting binding data and expression data for each knockdown.

(a) Example Venn diagrams showing the overlap of binding and differential expression for the knockdowns of HCST and IRF4 (the same genes as in Figure 1). (b) Boxplot summarizing the distribution of the fraction of all expressed genes that are bound by the targeted gene or downstream factors. (c) Boxplot summarizing the distribution of the fraction of bound genes that are classified as differentially expressed, using an FDR of either 5% or 20%.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1004226.g003