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Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice

Figure 2

The prevalence of heterogeneity in effect size of significant loci.

Each dot represents association between SNPs and HDL phenotype from applying random effects based meta-analysis approach. Dots with larger value represents the existence of more heterogeneity at the locus between studies. The distribution of the heterogeneity statistic for significant SNPs (red dots) in the meta analysis is skewed toward higher heterogeneity while the non-significant SNPs are much less skewed.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1004022.g002