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Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice

Figure 1

Application of Meta-GxE to Apoa2 locus.

The forest plot (A) shows heterogeneity in the effect sizes across different studies. The PM-plot (B) predicts that 7 studies have an effect at this locus, even though only 1 study (HMDP-chow(M)) is genome-wide significant with P-value.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1004022.g001