Genome Sequencing Highlights the Dynamic Early History of Dogs
(A) Box plots of heterozygosity measured in 5000 100 kb windows for each sample. (B) Reconstruction of historical patterns of effective population size (Ne) for individual genome sequences. Based upon the genomic distribution of heterozygous sites using the pairwise sequential Markovian coalescent (PSMC) method of Li and Durbin 2011 . Time scale on the x-axis is calculated assuming a mutation rate of 1×10−8 per generation (see Text S8); estimates from the full data and 50 bootstraps are depicted by darker and lighter lines, respectively.