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Quantifying Missing Heritability at Known GWAS Loci

Figure 2

Local heritability around known GWAS loci.

Components of heritability inferred at previously known GWAS loci. computed from leading SNP effect-size; computed from joint model of all known and significant SNPs in region; local expectation computed from and fraction of genome analyzed; and computed from LD adjusted variance component over all loci. (*) indicates statistically significant increase over expectation after accounting for nine tests. Error bars show analytical standard error of estimate. Autoimmune traits (CD, RA, T1D, UC, and MS) excluded the well-studied MHC region.

Figure 2