Quantifying Missing Heritability at Known GWAS Loci
Components of heritability inferred at previously known GWAS loci. computed from leading SNP effect-size; computed from joint model of all known and significant SNPs in region; local expectation computed from and fraction of genome analyzed; and computed from LD adjusted variance component over all loci. (*) indicates statistically significant increase over expectation after accounting for nine tests. Error bars show analytical standard error of estimate. Autoimmune traits (CD, RA, T1D, UC, and MS) excluded the well-studied MHC region.