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Elevated Mutagenesis Does Not Explain the Increased Frequency of Antibiotic Resistant Mutants in Starved Aging Colonies

Figure 2

Actual number of observed mutations in 15 starved genomes is smaller than expected under a model of increased mutagenesis affecting the entire starved population.

Drawn are the distributions of the numbers of mutations observed in simulations of 1000 experiments, in which 15 genomes are sequenced, under three different average mutation frequencies: (A) 0.5 mutations per genome (25–fold higher than expected under current estimates of mutation rates, assuming 20 generations). (B) 3.58 mutation per genome (179–fold higher than expected under current estimates of mutation rates, assuming 20 generations). (C) 25 mutations per 15 genomes (25-fold higher than the number of mutations we observed in the 15 non-starved genomes we sequenced. Arrows represent actual number of mutations observed in the 15 starved genomes we sequenced.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1003968.g002