A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability
Figure 1
Involvement of H3 K56 deacetylation in the suppression of spontaneous mutagenesis in the yeast S. cerevisiae.
Spontaneous mutation rates were measured as described in Materials and Methods. The data are shown as medians with 95% confidence intervals. The numbers above the bars are the relative mutation rates. (A) and (B) Effect of nicotinamide (NAM) on CAN1 (A) and his7-2 (B) mutation rates. The rates were measured in the haploid E134 strain (wild type) and indicated mutant derivatives exposed to 0-mM, 25-mM, or 50-mM NAM. (C) Effect of combining hst3Δ hst4Δ with msh2Δ, mlh1Δ, pol2-4, or pol3-5DV on spontaneous mutagenesis of CAN1 and his7-2.