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Dealing with the Evolutionary Downside of CRISPR Immunity: Bacteria and Beneficial Plasmids

Figure 5

Simulation of plasmid competition with CRISPR-mediated immunity.

Changes in the densities of different populations over time are plotted. Standard parameters (defined in Supplementary Text 2) are: ν = 1.4, e = 5×10−7, k = 1, γ = 10−14, initial values, R = 2500, CP = 200, D1 = 100, CN = D1 = D2 = T1 = T2 = 0. (A) Same rate of CRISPR loss (µ) and plasmid escape mutations (ν), µ = ν = 10−7. (B) High rate of plasmid escape mutants, µ = 10−7, ν = 3×10−4. (C) High rate of CRISPR loss or deletion mutations, µ = 3×10−4, ν = 10−7.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1003844.g005