The Molecular Mechanism of a Cis-Regulatory Adaptation in Yeast
Figure 4
Fitness effect of the causal mutation.
(A) In rich synthetic defined (SD) media, the RM AA112Δ strain and RM T229C strains show no significant difference from RM. (B) In the presence of the antifungal drug amphotericin B, the RM AA112Δ strain shows a growth rate advantage over RM, whereas the RM T229C strain shows no difference from RM. Bars represent the mean log2 ratios of log-phase growth rates from 48 replicate cultures, +/−1 S.E.