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Cell-Type Specific Features of Circular RNA Expression

Figure 7

Circular isoform expression patterns involves a variety of splicing patterns including proximal pairing and combinatorial expression.

Gene structures are represented along the axes with tick marks at splice site boundaries. Each circle is centered at the genomic coordinates corresponding to the donor and acceptor splice sites of the detected circular isoform. The length of the line segment is proportional to the log of the expression level of the circular isoform; the ring represents the maximum expression of the circular isoform across cell types. CYP24A1 and MCU exhibit striking expression preference for a single circular isoform. MBOAT2 exhibits a strong preference for a single splice acceptor site paired with multiple donors. ABCC1 exhibits preference for proximal pairs of splice donors and acceptors; CAMSAP1 exhibits a strong preference for either a particular single acceptor and or a particular single donor, whereas PICALM is an example of a gene with high combinatorial use of splice sites.

Figure 7

doi: https://doi.org/10.1371/journal.pgen.1003777.g007