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Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

Figure 3

Intersecting human and zebrafish genes by chromosome.

Data is shown for genes identified as human-zebrafish orthologs. Axes show genes by chromosome for human (left) and zebrafish (top). The cells in the matrix (intersections) show the overlap of orthologous genes on the individual zebrafish and human chromosomes. Circle and wedge sizes denote the number of genes. Note that the scales differ for the axes versus the intersections, as indicated. The red and blue colors denote recurrent gains and losses for either each individual organism (axes), or the shared changes in both organisms (intersections). The grey shows neutral changes; either no recurrent gain or loss for the per-organism chromosomal gene sets (axes), or lack of concordance (i.e. any combination of gain/loss, gain/neutral, neutral/neutral or loss/neutral) between human and zebrafish orthologs (intersections).

Figure 3