Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery
Gene-based Q-value profiles (JISTIC standard mode, −log10-transformed) summarizing the “amplification landscape” on chromosome 20 (A) and chromosome 25 (B), plotted above heatmaps (color scale on the very right) for all underlying 147 zebrafish MPNST samples. For each chromosome, samples are separated into two heatmap panels as indicated to the left of each panel: one for samples with focal and sub-chromosomal alterations (top) and another one for samples with large alterations comprising the entire chromosome (bottom). Within each panel, samples are sorted based on the amplitude at the primary peak (maximum −log10-transformed Q-values), or, for samples with focal alterations not supporting the primary profile peak, by a secondary peak. Diamond markers in profiles show gene locations. Genes with a described role in cancer are highlighted and labeled at the green arrows pointing to the corresponding heatmap regions of focal segment overlaps.