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Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

Figure 1

A regression plot illustrating the regression of Y on X.

The plot is annotated for the 2% extremes: red = 2% most intolerant, blue = 2% most tolerant. Five outlier genes with >140 common functional variant sites (y-axis) are not shown.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1003709.g001