Bacterial Adaptation through Loss of Function
Average exponential phase doubling times in defined media with (A) alanine, (B) glutamine, or (C) asparagine as the sole carbon source. ‘X’s denote individual measurements. Circles indicate mean doubling times. Of the 48 growth tests performed as a result of the transposon enrichment experiments (24 for alanine, 11 for glutamine, and 13 for asparagine), only the 24 strain/media combinations that grew significantly faster than the parental strain are shown (1-sided Mann-Whitney test, significance cutoff of 5% false discovery rate (FDR) for the entire dataset). Significant q-values are in Table S5. WT: wild-type.