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Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses

Figure 6

Polarity of stress-induced operons.

Graphs representing relative changes for selected operons after 90 min of singlet oxygen stress. Log2 ratios were derived from transcriptomic (Total 90 min, black bars), translatomic (Poly 90 min, red bars), and proteomic (SILAC 90 min, blue bars) data sets. Orientation of genes within operons is depicted from the left to the right, irrespective of their location in the genome, with the leftmost gene representing the first gene in the operon. Gene numbers refer to corresponding RSP-numbers. Operons were selected according to following categories: transport process and iron metabolism (A), RpoE-dependent (B, C, D), stress defense (C), transport process (D), chaperone (E), RpoH2-dependent (F, G), carbohydrate metabolism (F), redox reaction (G), protease (H).

Figure 6

doi: https://doi.org/10.1371/journal.pgen.1003576.g006