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A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

Figure 4

DNA methylation of RALBP1 is associated with a decrease in gene expression.

A CpG site in the promoter region of RALBP1 showed A) increased DNA methylation in response to exercise as well as B) a decrease in mRNA expression. C) In vitro DNA methylation of the RALBP1 promoter decreased gene expression, as measured by luciferase activity. The result represents the mean of three independent experiments, and the values in each experiment are the mean of five replicates (background control subtracted). Data is presented as mean ± SEM.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1003572.g004