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A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

Figure 3

DNA methylation of individual CpG sites.

The absolute change in DNA methylation of individual CpG sites with a significant difference after exercise compared with baseline (q<0.05) ranges from 0.2–10.9% (A and B). A) Number of sites with increased methylation in adipose tissue in response to exercise (n = 16,470). B) Number of sites with decreased DNA methylation in adipose tissue in response to exercise (n = 1,505). Panels C and D show the distribution of CpG sites with a significant change (q<0.05) and an absolute difference ≥5% in DNA methylation in adipose tissue before versus after exercise, in comparison to all analyzed sites on the Infinium HumanMethylation450 BeadChip. C) Distribution of significant CpG sites vs. all analyzed sites in relation to nearest gene regions. D) Distribution of significant CpG sites vs. all analyzed sites in relation to CpG island regions. *The overall distribution of significant CpG sites compared with all analyzed sites on the Infinium HumanMethylation450 BeadChip was analyzed using a chi2 test.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1003572.g003