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A Statistical Framework for Joint eQTL Analysis in Multiple Tissues

Figure 5

Example of an eQTL wrongly called as tissue-specific by the tissue-by-tissue analysis.

A. Boxplots of the PC-corrected expression levels from gene CHPT1 (Ensembl id ENSG00000111666) in all three cell types, color-coded by genotype class at SNP rs10860794. B. Forest plot of estimated standardized effect sizes of this eQTL. Note that, from the of the tissue-by-tissue analysis, the eQTL is significant at FDR = 0.05 only in fibroblasts.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1003486.g005