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From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes

Figure 1

Functional and evolutionary characteristics of essential genes.

A) Distribution of the 2472 essential genes (EG) across the genome (obtained from www.ensembl.org). B) Essential genes are significantly enriched in HGMD disease genes (P = 1.73×10−14), haploinsufficient genes [21] (P = 1.75×10−33) and ubiquitously expressed genes (P = 9.23×10−21) when compared to NLG. C) Comparison of non-synonymous to synonymous substitution rates between human and rhesus, chimp, mouse and rat in EG, NLG and ALL. Plotted substitution rates are normalized to Z-scores relative to the genome average.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1003484.g001