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Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

Figure 1

TE occurrence in lncRNAs.

See text, Methods and Table 1 for more details about lncRNA datasets. A. Percentage of transcripts with at least one exon overlapping with a TEs fragment (at least 10 bp). In red, lncRNAs (human = Gencode v13; mouse = both sets). Rest corresponds to human Refseq 57: in green, small non-coding RNAs (tRNAs and sno/miRNAs); in blue, protein-coding genes (pc genes) separated in exon types (coding and non-coding = UTRs); in black, pseudo = pseudogenes. B. Distribution of percentage of human lncRNA transcripts (Gencode v13) derived from TEs (more than 0% to more than 95%). The number of transcripts with more than 80% and more than 50% TE-derived DNA exons are indicated. Distribution is also shown for the subset of 36 studied lncRNAs presented in Table 2 and Table S2.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1003470.g001