Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
The proportion of GWAS significant SNPs (θP) is defined as the proportion of SNPs that passed a threshold P value (e.g. 0.01) in GWAS. Panel A): correlations (r) between θP and across 47 traits (all traits except INS0 and HOMA) for a range of threshold p-values. The maximum r value (rmax = 0.960) is at a threshold p-value of 0.031. Panel B): estimates of against θP at p-value of 0.031 for the 47 traits.