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Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

Figure 1

Estimate of variance explained by all SNPs ( ) versus proportion of GWAS significant SNPs.

The proportion of GWAS significant SNPs (θP) is defined as the proportion of SNPs that passed a threshold P value (e.g. 0.01) in GWAS. Panel A): correlations (r) between θP and across 47 traits (all traits except INS0 and HOMA) for a range of threshold p-values. The maximum r value (rmax = 0.960) is at a threshold p-value of 0.031. Panel B): estimates of against θP at p-value of 0.031 for the 47 traits.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1003355.g001