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RNAi–Based Functional Profiling of Loci from Blood Lipid Genome-Wide Association Studies Identifies Genes with Cholesterol-Regulatory Function

Figure 3

Comparison of multiparametric datasets for neighboring genes within lipid-trait-associated loci.

Shown are parameters “total cellular intensity” (“total”) of the two strongest effector siRNAs/gene and relative genomic position of lead SNPs (arrowheads) for seven (A–G) selected lipid-trait/CAD/MI loci in which multiple neighboring candidate genes (±50 kB up-/downstream of lead SNP) were functionally analyzed (see Figure S2 and Table S4 for comprehensive datasets). Phenotypes (red, increasing; blue, decreasing) meeting statistical criteria as described in Materials and Methods are framed in orange.

Figure 3