An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development
Figure 3
IC50 curves of flap endonuclease inhibitors.
FEN1 assays were carried out as described in Materials and Methods. Compound names are indicated above each graph, and structures are given to the right of each graph. Tumey 16 (top-left panel) was included as a positive control for flap endonuclease inhibition.