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Rbfox1 Downregulation and Altered Calpain 3 Splicing by FRG1 in a Mouse Model of Facioscapulohumeral Muscular Dystrophy (FSHD)

Figure 3

Alternative splicing changes in muscles of mice over-expressing FRG1.

Average linkage clustering was applied to alternative cassette exon splicing events with |Sepscore|≥0.3 in at least one of the four comparison datasets (q = 0). Selected nodes are expanded on the right. Exons which shown increased inclusion in FRG1 over-expressing muscles are shown in yellow in the heatmap, while exons with decreased inclusion are represented in blue.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1003186.g003