Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets
Figure 3
Schematics view of insulin regulation.
Elevated glucose level by either food intake or liver glycogenolysis is sensed by islet and leads to insulin secretion to the bloodstream. The increased insulin stimulates peripheral tissues to absorb glucose, and as a consequence, the glucose level in the plasma would return to normal level. Since a loop is formed regarding insulin regulation, it is necessary for us to consider both casual and reactive genes to insulin.