Cul3 and the BTB Adaptor Insomniac Are Key Regulators of Sleep Homeostasis and a Dopamine Arousal Pathway in Drosophila
Figure 10
3IY rescues sleep homeostasis defects in Cul3-RNAi and incf00285 but not incmw.
The graph shows the percent change in sleep (%Δsleep) after 12 h of mechanical sleep deprivation (red), 6 h of sleep recovery (light blue), and 9 h of sleep recovery (dark blue) in iso31, elav-Gal4;Cul3-RNAi/UAS-dcr2 (Cul3-RNAi), incf00285, and incmw with 2 mg/mL 3IY (light green), 10 mg/mL 3IY (dark green) or no 3IY. n≥41 females for all conditions. * p<0.05. Error bars are SEM.