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Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2

Figure 3

EcR-B1, EcR-B2, and CRC regulated ETH expression.

(A) Inka cell-specific crc RNAi lowered ETH transcript levels (n = 9, crc RNAi; n = 6, ETH-GSW>+controls). *, p<0.05; **, p<0.01 (One-way ANOVA: TM5, p = 0.01225; TM8, p = 0.001375). (B) Inka cell-specific expression of dominant negative EcR-B1-W650A or EcR-B2-W650A (EcR-B1 DN or EcR-B2 DN) lowered ETH transcript levels (n = 9, dominant negatives; n = 23, Oregon R controls). **, p<0.01; ***, p<0.001 [One-way ANOVA with Bonferroni (all-pairwise) multiple comparison test: TM5, p = 0.000265; TM8, p = 0.000044]. Bar = 20 ┬ÁM.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1002883.g003