S Phase–Coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues
Figure 3
E2f1Stable acts acutely to trigger apoptosis.
A–E) Detection of S phase by EdU labeling (red) and apoptosis by CC3 staining (green) in GMR-Gal4 third instar larval eye imaginal discs expressing GFP or the indicated GFP-E2f1 fusion proteins. Arrowheads indicate the position of the MF, with anterior to the left and posterior to the right. Bars = 5 µM. F) Quantification of the number of CC3 positive cells posterior to the MF. * p<0.001 relative to UAS-E2f1 expression.