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Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection

Figure 5

Species-specific DHS sites are associated with functional chromatin marks.

DHS sites detected only in human, but not chimpanzee, LCLs are more enriched for ChIP signals in matched human cell types. LCL histone modification and CTCF ChIP-seq data were previously generated from the GM12878 cell line [33]. Fisher's exact test P value significance levels indicated by asterisks or NS (not significant) are provide for LCL human DHS gains compared to LCL human DHS loss and LCL common DHS regions (Table S6).

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1002789.g005