Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Figure 1
DNA methylation variation associates with genetic variation.
A. Genome-wide pair-wise correlation coefficients in 21 pairs of MZ twins, 31 pairs of DZ twins, and 1091 pairs of unrelated individuals. B. Histogram of the observed distribution of P-values (black bars) and the expected distribution (red area indicates 90% confidence region) obtained from ten permutations of the data. C. Majority of SNPs that are cis-meQTLs are located within few kb of the methylation probe. D. Overlap of probes that have cis-meQTLs from the current study (red) with probes reported to have meQTLs in brain tissues (blue, [3]) and in LCLs (grey, [1]), not accounting for SNP overlap.