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Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

Figure 1

Manhattan plot of all meta-analysis results performed in PDGene.

This summary combines association results from 7,123,986 random-effects meta-analyses based on the March 31st 2011 datafreeze of the PDGene database. Results are plotted as −log10 P-values (y-axis) against physical chromosomal location (x-axis). Black and grey dots indicate results originating exclusively from the three fully publicly available GWAS datasets [10], [12], [13] (see Methods), while green dots are based on a combination of smaller scale studies, supplemented by GWAS datasets (where applicable). Gene annotations are provided for genes highlighted in the main text.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1002548.g001