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Ultrafast Evolution and Loss of CRISPRs Following a Host Shift in a Novel Wildlife Pathogen, Mycoplasma gallisepticum

Figure 5

Evolution of the CRISPR locus in Mycoplasma gallisepticum isolates collected from House Finches, chickens, and turkeys.

Numbers by each strain indicate the number of repeats in each CRISPR array. The ancestral 71-repeat CRISPR array of the chicken MG strain is shown in simplified form at bottom. Diagnostic CRISPR repeats for House Finch MG isolates are indicated in repeat-specific patterns. The black ovals signify the cluster of four CRISP-associated (CAS) genes, which are deleted in the 2007 strains. The tree at left is broadly consistent with the tree based on SNPs (Figure 3) but emphasizes strain clusters indicated by rare genomic changes and CRISPR deletions; it was constructed as described in Text S3.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1002511.g005