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Cell Lineage Analysis of the Mammalian Female Germline

Figure 6

Depth-guided oocyte selection for ovulation accounts for the increase in oocyte depth with age.

(a) Depth-guided oocyte maturation. Shown is a hypothetical tree showing entry into meiosis during embryonic development. The hypothesis states that oocytes that enter meiosis first during embryonic life would be ovulated first during post-natal life. (b) Comparison of median depth of oocytes isolated from pre antral follicles isolated from 12 day-old mice vs. oocytes isolated pre ovulatory follicles isolated from older mice. Each point is the median of the depths of all oocytes sampled from a single mouse. (c) Depth distributions of oocytes from pre-antral follicles in 12 day-old mice are not significantly different from the expectation from the production line hypothesis. Shown is the expected distribution of median depth of oocytes assuming that the depth distribution at birth is a uniform average of all measured post-natal depth values of maturing oocytes. Filled circles denote the observed median depth in the two 12 day old mice. Error bars are standard errors of the means.

Figure 6

doi: https://doi.org/10.1371/journal.pgen.1002477.g006