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Cell Lineage Analysis of the Mammalian Female Germline

Figure 1

Oocytes form a cluster distinct from bone marrow cells.

Reconstructed cell lineage tree of mice in several ages, each showing that GV oocytes from large antral follicles (red) form a cluster that is distinct from cells of bone marrow origin (mesenchymal stem cells- yellow and lymphocytes-blue). Ovarian cumulus cells are in green. Shaded boxes denote subtrees that are statistically enriched for cells of a certain cell population, using a hyper-geometric enrichment test. Mouse names represent their age in days. Y axis is depth (number of divisions since the zygote). One cell in M278 was cropped for visual clarity.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1002477.g001