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Adaptive Evolution of the Lactose Utilization Network in Experimentally Evolved Populations of Escherichia coli

Figure 9

Fitness effect of lacI and lacO1 mutations depend on genetic background.

The fitness effect of lacO1 and lacI mutations were measured in the ancestor and the G+L3-1 evolved genetic backgrounds when competed in the G+L environment. Gray points indicate fitness effect in competitions against the corresponding progenitor strains that do not have the added lac mutation; black points indicate fitness of lacI and lacO1 mutations competed directly against each other. Lines connect competitions of the same type but in different genetic backgrounds.

Figure 9