The Drosophila melanogaster Seminal Fluid Protease “Seminase” Regulates Proteolytic and Post-Mating Reproductive Processes
Seminase is cleaved during mating within the male reproductive tract where it is required for CG11864 cleavage. CG11864 then regulates processing of two SFPs, ovulin and Acp36DE (left branch). Seminase is also necessary for the long term response (LTR) pathway (right branch). Proteins/pathways downstream of seminase are involved in the processes shown in boxes, based on earlier knockout or knockdown studies. The consequences of proteolytic processing of ovulin and Acp36DE remain unknown.