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Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity

Figure 4

Temperature-sensitive lethality of the xbp-1;pek-1 double mutant.

(A) Development of the xbp-1(tm2482); pek-1(ok275) mutant across physiological temperatures. Values represent average fraction of eggs developed to the indicated stage ± s.e.m. (n = 3 independent experiments at 20°C, 2 independent experiments at all other temperatures; ***P<0.001, two-way ANOVA with Bonferroni post test). (B) Lifespan of indicated strains grown at 16°C to the L4 stage, then shifted to either 16°C to 25°C. Results are representative of two independent experiments.

Figure 4