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Evidence for Hitchhiking of Deleterious Mutations within the Human Genome

Figure 5

Enrichment of disease-associated alleles in hitchhiking relative to non-hitchhiking regions.

Each category shows the number within hitchhiking to non-hitchhiking regions, where hitchhiking regions were defined by the overlap of three or more tests of selection. Neutral SNPs are from HapMap Phase II. Disease alleles in 1000 Genomes columns are based on the Human Gene Mutation Database. The sample size of each category is shown in parentheses. Bars show one-sided Fisher's Exact test comparisons, not significant (ns), P<0.05 (*), P<0.01 (**), and P<0.001 (***).

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1002240.g005