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Variance of Gene Expression Identifies Altered Network Constraints in Neurological Disease

Figure 2

Expression variance is stable under different normalization strategies.

A. Assessing the impact of normalization strategies on genome-wide variance distribution for the hONS stem cells and fibroblasts from the control group. B. Venn diagram demonstrating the geneset overlap of low-variance (left) or high-variance (right) identified from representative normalization strategies. There was a >75% concordance in the low-variance groups and a >90% concordance in the high-variance groups.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1002207.g002