Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs
Figure 1
ERRα is involved in diurnal glucose homeostasis.
Blood glucose measurements taken from fed ad libitum (A) and fasted (B) male WT and ERRα-null mice (n = 15 and n = 8 for A and B respectively) at 4 hr intervals over a 24 hr period from ZT 4 to ZT 24. Error bars represent ± SEM. Student's t test, *p<0.05. ZT 0 values are a duplicate of ZT 24 shown for clarity. (C) Blood glucose during a glucose tolerance test in WT and ERRα-null mice (n = 8) at ZT 12 following a 6 hr fast and intraperitoneal glucose administration of 2 mg/g body weight. Error bars represent ± SEM. Student's t test, *p<0.05. (D) Area under the glucose curve at ZT 12. Error bars represent ± SEM. (E) Blood glucose during a glucose tolerance test in WT and ERRα-null mice (n = 6) at ZT 0/24 following a 6 hr fast and intraperitoneal glucose administration of 2 mg/g body weight. Error bars represent ± SEM. Student's t test, *p<0.05. (F) Area under the glucose curve at ZT 0/24. Error bars represent ± SEM. Student's t test, *p<0.05. (G) Diurnal serum insulin levels in fed ad libitum WT and ERRα-null mice. Error bars represent ± SEM. Student's t test, *p<0.05. ZT 0 values are a duplicate of ZT 24 shown for clarity. (H) Blood glucose during a glucose tolerance test in WT and ERRα-null mice (n = 6) at ZT 16 following a 6 hr fast and intraperitoneal glucose administration of 2 mg/g body weight. Error bars represent ± SEM. Inset: area under the glucose curve at ZT 16. Error bars represent ± SEM.