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A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

Figure 5

Age-dependent decrease in the contribution of PMK-1 p38 MAPK signaling to C. elegans immunity.

(A) Survival of wild type strain N2 (orange) and the pmk-1(km25) mutant (blue) transferred from E. coli OP50 to P. aeruginosa PA14 at L4, and at Days 3, 6, and 9 of adulthood (B–D, respectively), plotted as fraction of worms alive versus time.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1002082.g005