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Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

Figure 2

eQTL characteristics.

(A,B) Manhattan plots depicting best associated cis-eQTLs for all gene expression traits in the UC (A) and UW (B) studies. Autosomes are ordered and alternately colored along the x-axis. BF of the SNP-gene pair is plotted on the y-axis. Probes overlapping common polymorphisms are plotted as triangles, probes without known SNPs are plotted as open circles. For display purposes, genes with UC BF>23 that replicate in the UW study are labeled with gene names. (C) Distribution of distances from each gene's best associated SNP to its TSS. Negative and positive values denote SNPs 5′ and 3′ of TSS, respectively. Data are plotted for all significant UC eQTLs (BF>5, black), eQTLs replicated in the UW (red), Merck (blue), and eQTLs replicated in either UW or Merck (green).

Figure 2