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Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis

Figure 4

Mice deficient for Asxl2 have decreased BMD.

Male mice deficient in Asxl2 (−/−) display significant decreases relative to wild-type controls (+/+) in (A) TBMD, (B) SBMD and (C) FBMD residuals after adjusted for age and body weight. (B) Female mice deficient in Asxl2 (−/−) display significant decreases relative to wild-type controls (+/+) in (D) TBMD, (E) SBMD and (F) FBMD residuals after adjusted for age and body weight. Data shown in all panels are residual means±SEM. *P<0.05.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1002038.g004