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Repeat Associated Non-ATG Translation Initiation: One DNA, Two Transcripts, Seven Reading Frames, Potentially Nine Toxic Entities!

Figure 1

RUNning a RAN-gene.

One DNA, two transcripts, seven possible reading frames, potentially nine toxic entities! Both CAG and CTG transcripts could be toxic [12], [38], the AUG-initiated polyGln protein reading frame can be toxic, and each of the three reading frames from either the CAG or CUG transcript present six additional homopolymeric proteins, making a total of nine potentially toxic entities!

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1002018.g001