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Origin-Dependent Inverted-Repeat Amplification: A Replication-Based Model for Generating Palindromic Amplicons

Figure 2

The Origin-Dependent Inverted-Repeat (ODIRA) model for Amplification of chromosomal segments.

(A) An overview of the release of a closed circular, self-complementary intermediate that arises from aberrant replication. (B) Details of the mechanism that leads to ligation of the leading and lagging strands at short, closely spaced, inverted repeats (IRs; labeled as a a′ and b b′). (C) Replication and reinsertion of the inverted dimeric amplicon into the genome by homologous recombination. See text for detailed explanations.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1002016.g002