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Origin-Dependent Inverted-Repeat Amplification: A Replication-Based Model for Generating Palindromic Amplicons

Figure 1

The chromosomal context for SUL1 amplification.

(A) The inverted repeat sequences in CTP1 and PCA1 that define the breakpoints of a specific SUL1 amplification event [7]. (B) The structure of the wild type SUL1 locus that includes the nearby origin of replication, ARS228. (C) The inferred structure of the head-to-head/tail-to-tail 5× SUL1 amplification product recovered after selective growth of a haploid yeast strain in medium limiting for sulfur.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1002016.g001